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dc.contributor.authorAnilakumar, K R-
dc.contributor.authorSudarshanakrishna, K R-
dc.contributor.authorChandramohan, G-
dc.contributor.authorIlaiyaraja, N-
dc.contributor.authorKhanum, Farhath-
dc.contributor.authorBawa, A S-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractThe present work was undertaken with a view to study the effect of oral feeding of 2% Aloe vera gel extract (AGE) for 30 days on azoxymethane (AOM)-induced oxidative stress in rats. It was observed that AOM administration resulted in a significant increase in malondialdehyde and conjugated dienes, with reduction in hepatic glutathione (GSH), vitamin A and uric acid contents. AOM-induced reduction in hepatic GSH and uric acid was brought back to normal by AGE. There was a significant raise in hepatic catalase, superoxide dismutase and glucose-6-phosphate dehydrogenase (G-6-PD) activities as a result of feeding of the extract. Ingestion of the extract effected reduction in AOM-induced colonic GSH-peroxidase, G-6- PD and glutathione S-transferase and femur bone marrow micronuclei formation. Hence, it is suggested that Aloe vera gel extract possess the ability to reduce AOM- induced oxidative stress and toxicity in liver.en_US
dc.sourceIJEB Vol.48(08) [August 2010]en_US
dc.subjectAloe vera gel extracten_US
dc.subjectDetoxifying enzymesen_US
dc.subjectRat liveren_US
dc.titleEffect of Aloe vera gel extract on antioxidant enzymes and azoxymethane-induced oxidative stress in ratsen_US
Appears in Collections:IJEB Vol.48(08) [August 2010]

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