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Title: Effect of Aloe vera gel extract on antioxidant enzymes and azoxymethane-induced oxidative stress in rats
Authors: Anilakumar, K R
Sudarshanakrishna, K R
Chandramohan, G
Ilaiyaraja, N
Khanum, Farhath
Bawa, A S
Keywords: Aloe vera gel extract;Azoxymethane;Detoxifying enzymes;Micronuclei;Rat liver
Issue Date: Aug-2010
Publisher: CSIR
Abstract: The present work was undertaken with a view to study the effect of oral feeding of 2% Aloe vera gel extract (AGE) for 30 days on azoxymethane (AOM)-induced oxidative stress in rats. It was observed that AOM administration resulted in a significant increase in malondialdehyde and conjugated dienes, with reduction in hepatic glutathione (GSH), vitamin A and uric acid contents. AOM-induced reduction in hepatic GSH and uric acid was brought back to normal by AGE. There was a significant raise in hepatic catalase, superoxide dismutase and glucose-6-phosphate dehydrogenase (G-6-PD) activities as a result of feeding of the extract. Ingestion of the extract effected reduction in AOM-induced colonic GSH-peroxidase, G-6- PD and glutathione S-transferase and femur bone marrow micronuclei formation. Hence, it is suggested that Aloe vera gel extract possess the ability to reduce AOM- induced oxidative stress and toxicity in liver.
Page(s): 837-842
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(08) [August 2010]

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