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Title: Synthesis and biological activity of some 3-imidazo[1,2-]pyridin-2-yl-chromen-2-one and 3-indolizin-2-yl-chromen-2-one
Authors: Kumar, P Vijaya
Rao, V Rajeswar
Keywords: Coumarins;aminopyridines;cyclization reaction;indolizines;antitubercular;antiviral;anticancer
Issue Date: Oct-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D 209/04 // A 61 P 31/06, 31/12, 35/00
Abstract: Condensation of 3-(2-bromoacetyl)coumarins 1 with various 2-aminopyridines 2 in the solid state under solvent-free conditions yield 3-imidazo[1,2- ]pyridin-2-yl-chromen-2-ones 3. Condensation of 1 with 2-methylpyridines in dry benzene affords N-alkylpyridinium salts 5. These undergo cyclization reaction when heated with sodium bicarbonate to give indolizines 6. The structures of newly prepared compounds have been confirmed from analytical and spectral data. Some of the compounds exhibit antitubercular, antiviral and anticancer activities.
Page(s): 2120-2125
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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