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Title: Synthesis of potential fungicidal bibenzyls from bio-renewable source
Authors: Siddiqui, Ibadur R
Singh, Jaya
Singh, Pravin K
Singh, Jagdamba
Keywords: Bibenzyls;condensation;aryl amines;Schiff’s bases;neucleophilic addition;2-mercaptopropionic acid;microwave irradiation;antifungal screening
Issue Date: Jul-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 C 15/00 // A 61 P
Abstract: Acetylation of bibenzyl 1 yields 4,4'-diacetylbibenzyl 2, which on condensation with different aryl amines gives corresponding Schiff’s bases in situ. Nucleophilic addition of 2-mercaptopropionic acid or 2-mercaptosuccinic acid on Schiff’s bases followed by cyclodehydration in solvent-free condition under microwave irradiation affords 4,4'-bis(3"-aryl-2"-methyl-5"-methyl/carboxymethyl-4"-oxo-thiazolidin-2"-yl)bibenzyl 3a-n with excellent yield (88-94%). The rate of the reaction is enhanced 225 times in comparison with conventional method. Antifungal screening results on Fusarium oxysporum and Penicillium citrinum show that most of the synthesized compounds display promising antifungal activity, comparable with Griseofulvin and Dithane M-45 as standards.
Page(s): 1460-1464
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(07) [July 2005]

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