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http://nopr.niscpr.res.in/handle/123456789/8940| Title: | Candida rugosa lipase-mediated enantioselective acetylation studies on (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydro-1-benzopyran-4(H)-ones |
| Authors: | Trikha, Smriti Kumar, Rajesh Dhawan, Ashish Poonam Prasad, Ashok K Cholli, Ashok L Olsen, Carl E Watterson, Arthur C Parmar, Virinder S |
| Issue Date: | Feb-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 311/04 |
| Abstract: | Candida rugosa lipase, catalyzed enantioselective acetylation reactions have been performed on novel (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydrobenzopyran-4-ones in diisopropyl ether. The Candida rugosa lipase-catalyzed acetylations exhibit the enantiomeric separation of the racemic compounds 5a-g, the enantioselectivity of the reaction has been found to be highly dependent on the structure of the substrate. The enantiomeric excess (ee) values are determined by 1H NMR spectral analysis of their O-acetylmandelic acid esters and highest enantiomeric excess obtained is 79% in case of 5c. |
| Page(s): | 356-365 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(02) [February 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(2) 356-365.pdf | 158.2 kB | Adobe PDF | View/Open |
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