Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/8483
Title: | Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats |
Authors: | Mahesh, Radhakrishnan Pandey, Dilip Kumar Katiyar, Shruti Kukade, Gaurav Viyogi, Shruti Rudra, Anjuman |
Keywords: | Anti-depressants;Anxiety;Depression;Traumatic brain injury |
Issue Date: | May-2010 |
Publisher: | CSIR |
Abstract: | Disruption of normal neuronal networks and neurotransmitters like serotonin and norepinephrine levels in post traumatic brain injury (TBI) are observed to be the primary causative agent for depression/anxiety. This communication reports the efficacy of various classes’ anti-depressants in the treatment of depression/anxiety following TBI in rats. Chronic treatment with anti-depressants (escitalopram and venlafaxine) leads to improvement in the depressive/anxiogenic -like behaviour in the TBI rat and corroborates the notion of the involvement of serotonin and norepinephrine in the behavioural consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine significantly reversed the effect of TBI as compared to vehicle-treated TBI group. The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury. |
Page(s): | 466-473 |
ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
Appears in Collections: | IJEB Vol.48(05) [May 2010] |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IJEB 48(5) 466-473.pdf | 290.18 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.