Anti-allergic, anti-inflammatory and anti-lipidperoxidant effects of <i style="">Cassia occidentalis</i> Linn.

Abstract

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<i style="">Cassia occidentalis </i>Linn. mast cell degranulation at a dose of 250 mg/kg, showed dose dependent stabilizing activity towards human RBC, with is widely used in traditional medicine of India to treat a number of clinical conditions including allergy and inflammatory manifestations. In the present study anti-allergic, anti-inflammatory and anti-oxidant properties of <i style="">C. occidentalis </i>whole plant ethanolic extract (CO)<i style=""> </i>was investigated. Effects of CO on rat mast<i style=""> </i>cell degranulation inhibition and human red blood cell (HRBC) membrane stabilization were studied <i style="">in vitro</i> following standard methods. The anti lipidperoxidant effects of CO were also studied <i style="">in vitro</i>. Effect of CO on carrageenan-induced mouse paw oedema inhibition was also assessed. CO significantly decreased maximum protection of 80.8% at 15 μg/ml. The extract also caused significant reduction in malondialdehyde (MDA) levels of murine hepatic microsomes at 100 μg/ml (56%) and significantly reduced carrageenan induced inflammation in mice at a dose of 250 mg/kg. Results of the present study indicated that CO inhibited mast cell degranulation, stabilized HRBC membrane thereby alleviating immediate hypersensitivity besides showing anti oxidant activity.

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