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Title: Antitussive effect of Cuminum cyminum Linn. in guinea pigs
Authors: Boskabady, Mohammad Hossin
Kiani, Sahar
Azizi, Hoda
Khatami, Tahereh
Keywords: Cuminum cyminum;Cumin;Antitussive;Citric acid;Codeine
Issue Date: Aug-2006
Publisher: CSIR
IPC Code: Int. cl.7 — A 61 K 35/78, A61P 11/14
Abstract: Several therapeutic effects including the effect on asthma and dyspnoea have been described for the seeds of cumin, Cuminum cyminum Linn. In the present study the antitussive effect of this plant was evaluated. The antitussive effects of aerosols of two different concentrations of aqueous and macerated extracts, Codeine and saline were tested  on guinea pigs by counting the number of coughs produced due to aerosol of citric acid 10 minutes after exposing animal to aerosols of different solutions (n=5 for each solution). The results showed significant reduction of cough number in the presence of both concentrations of aqueous and macerated extracts and Codeine (P<0.01 to P<0.001). The cough number observed in the presence of higher concentrations of aqueous and macerated extracts were not significantly different than those of lower concentrations. In addition, there was no significant difference between cough numbers observed in the presence of both concentrations of extracts with that of Codeine. These results indicated an antitussive effect of cumin which was comparable to that of Codeine.
Page(s): 266-269
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.5(4) [July-August 2006]

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