Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSiddiqui, Ibadur R-
dc.contributor.authorSingh, Pravin K-
dc.contributor.authorSrivastava, Vishal-
dc.contributor.authorSingh, J-
dc.description.abstractMicrowave induced montmorillonite K 10 clay catalyzed Michael addition of sulphur nucleophile, (4-oxo-butyl)-dithio­carbamic acid 1 to 4-arylidene-5(4H)-oxazolones 2a-j followed by ring transformation of the resultant Michael adducts 3a-j in solvent-free conditions gives 4a-j in excellent yield. Coexistence of acidic and basic sites on surface of montmoril­lonite K 10 accelerates the organic reactions synergistically. The control Aldol condensation of compound 4a-j with HCHO gives compound 5a-j, which upon chemoselective reduction with NaBH4 gives the title compound 6a-j.  This process minimizes the mechanical loss of the intermediate during the process of isolation, and thus increases the yield and decreases the cost and time.en_US
dc.sourceIJC-B Vol.49B(04) [April 2010]en_US
dc.subjectMichael additionen_US
dc.subjectmontmorillonite K 10en_US
dc.subjectcontrol aldol condensationen_US
dc.subjectchemoselective reductionen_US
dc.subjectmicrowave irradiationen_US
dc.titleFacile synthesis of acyclic analogues of carbocyclic nucleoside as potential anti-HIV pro-drugen_US
Appears in Collections:IJC-B Vol.49B(04) [April 2010]

Files in This Item:
File Description SizeFormat 
IJCB 49B(4) 512-520.pdf155 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.