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http://nopr.niscpr.res.in/handle/123456789/7937| Title: | Facile synthesis of acyclic analogues of carbocyclic nucleoside as potential anti-HIV pro-drug |
| Authors: | Siddiqui, Ibadur R Singh, Pravin K Srivastava, Vishal Singh, J |
| Keywords: | Michael addition;montmorillonite K 10;control aldol condensation;chemoselective reduction;microwave irradiation |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | Microwave induced montmorillonite K 10 clay catalyzed Michael addition of sulphur nucleophile, (4-oxo-butyl)-dithiocarbamic acid 1 to 4-arylidene-5(4H)-oxazolones 2a-j followed by ring transformation of the resultant Michael adducts 3a-j in solvent-free conditions gives 4a-j in excellent yield. Coexistence of acidic and basic sites on surface of montmorillonite K 10 accelerates the organic reactions synergistically. The control Aldol condensation of compound 4a-j with HCHO gives compound 5a-j, which upon chemoselective reduction with NaBH4 gives the title compound 6a-j. This process minimizes the mechanical loss of the intermediate during the process of isolation, and thus increases the yield and decreases the cost and time. |
| Page(s): | 512-520 |
| Appears in Collections: | IJC-B Vol.49B(04) [April 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 49B(4) 512-520.pdf | 155 kB | Adobe PDF | View/Open |
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