Ameliorative effect of a combination of vitamin E, vitamin C, <img src='/image/spc_char/alpha.gif' border=0>- lipoic acid and stilbene resveratrol on lindane induced toxicity in mice olfactory lobe and cerebrum

Abstract

Acute dose of lindane (40 mg/kg body weight, ip) caused significant reduction in butyrylcholinesterase (BChE) activity both in olfactory lobe and cerebrum of mice along with reduction in catalase (CAT), total protein and elevation in superoxide dismutase (SOD) and cholesterol contents. Pretreatment by a combination of antioxidants, vitamin E, vitamin C, <img src='/image/spc_char/alpha.gif' border=0>- lipoic acid and stilbene resveratrol (125 mg/kg body weight, ip) significantly augment the altered level of BChE and protect the other parameters in both the brain regions. The results were adequately in agreement with the histochemical findings, suggesting the neuroprotective efficacy of combination of antioxidants studied on the lindane induced neurotoxicity.