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DC Field | Value | Language |
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dc.contributor.author | Kumar, Vijayendra | - |
dc.contributor.author | Rajesh Kumar | - |
dc.contributor.author | Raunak | - |
dc.contributor.author | Poonam | - |
dc.contributor.author | Sharma, Sunil K | - |
dc.contributor.author | Prasad, Ashok K | - |
dc.contributor.author | Cholli, Ashok L | - |
dc.contributor.author | Olsen, Carl E | - |
dc.contributor.author | Parmar, Virinder S | - |
dc.date.accessioned | 2008-04-03T09:36:03Z | - |
dc.date.available | 2008-04-03T09:36:03Z | - |
dc.date.issued | 2007-09 | - |
dc.identifier.issn | 0376-4699 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/691 | - |
dc.description | 1501-1510 | en_US |
dc.description.abstract | (±)-3-Aryl-3-hydroxymethyl-2,3-dihydro-4H-1- benzopyran-4-ones have been synthesized in four steps starting with the coupling of resorcinol with corresponding phenylacetic acid leading to the formation of 2,4-dihydroxyphenyl aryl ketones, which upon monomethylation/benzylation and hydroxymethylation afford (±)-hydroxymethylisoflavanones in 65-70% yields. These isoflavanones have been subjected to lipase-catalyzed acylation reactions under different conditions (for optimization) of varying solvents, enzymes and acylating agents. Candida antarctica lipase B in tetrahydrofuran using heptanoic anhydride at 90 ºC is found to be the best reaction protocol for the biocatalytic reaction. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | CSIR | en_US |
dc.source | IJCB Vol.46B(9) [September 2007] | en_US |
dc.subject | Isoflavanones | en_US |
dc.subject | Biocatalytic resolution | en_US |
dc.subject | Lipase | en_US |
dc.subject | CAL-B | en_US |
dc.subject | Acylating agents | en_US |
dc.subject | Heptanoic anhydride | en_US |
dc.title | Biocatalytic acylation studies on novel 3-aryl-3-hydroxymethyl-2, 3-dihydro-4H-1- benzopyran-4-ones | en_US |
dc.type | Article | en_US |
Appears in Collections: | IJC-B Vol.46B(09) [September 2007] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 46B(9) (2007) 1501-1510.pdf | 156.56 kB | Adobe PDF | View/Open |
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