Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/691
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dc.contributor.authorKumar, Vijayendra-
dc.contributor.authorRajesh Kumar-
dc.contributor.authorRaunak-
dc.contributor.authorPoonam-
dc.contributor.authorSharma, Sunil K-
dc.contributor.authorPrasad, Ashok K-
dc.contributor.authorCholli, Ashok L-
dc.contributor.authorOlsen, Carl E-
dc.contributor.authorParmar, Virinder S-
dc.date.accessioned2008-04-03T09:36:03Z-
dc.date.available2008-04-03T09:36:03Z-
dc.date.issued2007-09-
dc.identifier.issn0376-4699-
dc.identifier.urihttp://hdl.handle.net/123456789/691-
dc.description1501-1510en_US
dc.description.abstract(±)-3-Aryl-3-hydroxymethyl-2,3-dihydro-4H-1- benzopyran-4-ones have been synthesized in four steps starting with the coupling of resorcinol with corresponding phenylacetic acid leading to the formation of 2,4-dihydroxyphenyl aryl ketones, which upon monomethylation/benzylation and hydroxymethylation afford (±)-hydroxymethylisoflavanones in 65-70% yields. These isoflavanones have been subjected to lipase-catalyzed acylation reactions under different conditions (for optimization) of varying solvents, enzymes and acylating agents. Candida antarctica lipase B in tetrahydrofuran using heptanoic anhydride at 90 ºC is found to be the best reaction protocol for the biocatalytic reaction.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJCB Vol.46B(9) [September 2007]en_US
dc.subjectIsoflavanonesen_US
dc.subjectBiocatalytic resolutionen_US
dc.subjectLipaseen_US
dc.subjectCAL-Ben_US
dc.subjectAcylating agentsen_US
dc.subjectHeptanoic anhydrideen_US
dc.titleBiocatalytic acylation studies on novel 3-aryl-3-hydroxymethyl-2, 3-dihydro-4H-1- benzopyran-4-onesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.46B(09) [September 2007]

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