Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSimon, Jerine Peter-
dc.contributor.authorNithiyanandam, Sangeetha-
dc.contributor.authorKatturajan, Ramkumar-
dc.contributor.authorParthasarathy, Manisha-
dc.contributor.authorNamachivayam, Arunraj-
dc.contributor.authorBhaskarmurthy, Deepak Hiraganahalli-
dc.contributor.authorR, Vidya-
dc.contributor.authorPrince, Sabina Evan-
dc.identifier.issn0975-0959 (Online); 0301-1208 (Print)-
dc.description.abstractDiclofenac medication has been extensively used for anti-inflammatory, anti-pyretic, and analgesic actions. Its abiding usage and overdose have induced toxicity and harmful effects on the liver, kidney, and gastrointestinal tract. The research aims to scrutinize the protective effect of Madhuca longifolia seed oil against diclofenac-induced toxicity in female Wistar albino rats. A period of 10 days of study was aimed at 7 groups; Group 1 was assigned as normal control. Group 2 has been administered diclofenac (50 mg/kg b.w. /day, i.p.) only on the last two days of each study period. Group 3 and Group 4 have been pre-treated with 1 mL, and 2 mL of Madhuca longifolia seed oil, respectively, and diclofenac was induced as per Group 2. Group 5 was treated with the standard drug silymarin and diclofenac. Group 6 and Group 7 were given 1 mL and 2 mL of Madhuca longifolia seed oil alone. After the study period, parameters like liver enzyme markers, renal enzyme markers, and antioxidants were measured, and tissue samples were analyzed for histopathological changes. The results proved that pre-treatment of 1 mL ofMadhuca longifolia seed oil has efficacy against diclofenac-induced toxicity.en_US
dc.publisherNIScPR-CSIR, Indiaen_US
dc.sourceIJBB Vol.60(03) [March 2023]en_US
dc.subjectGastrointestinal toxicityen_US
dc.subjectMadhuca longifolia seed oilen_US
dc.subjectRenal toxicityen_US
dc.titleSupplementation of Madhuca longifolia Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach Jen_US
Appears in Collections:IJBB Vol.60(03) [March 2023]

Files in This Item:
File Description SizeFormat 
IJBB-186-195.pdf2.41 MBAdobe PDFView/Open
IJBB-186-195suppl .pdf313.27 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.