Please use this identifier to cite or link to this item:
Title: Supplementation of Madhuca longifolia Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach J
Authors: Simon, Jerine Peter
Nithiyanandam, Sangeetha
Katturajan, Ramkumar
Parthasarathy, Manisha
Namachivayam, Arunraj
Bhaskarmurthy, Deepak Hiraganahalli
R, Vidya
Prince, Sabina Evan
Keywords: Antioxidant;Diclofenac;Gastrointestinal toxicity;Hepatotoxicity;Madhuca longifolia seed oil;Renal toxicity
Issue Date: Mar-2023
Publisher: NIScPR-CSIR, India
Abstract: Diclofenac medication has been extensively used for anti-inflammatory, anti-pyretic, and analgesic actions. Its abiding usage and overdose have induced toxicity and harmful effects on the liver, kidney, and gastrointestinal tract. The research aims to scrutinize the protective effect of Madhuca longifolia seed oil against diclofenac-induced toxicity in female Wistar albino rats. A period of 10 days of study was aimed at 7 groups; Group 1 was assigned as normal control. Group 2 has been administered diclofenac (50 mg/kg b.w. /day, i.p.) only on the last two days of each study period. Group 3 and Group 4 have been pre-treated with 1 mL, and 2 mL of Madhuca longifolia seed oil, respectively, and diclofenac was induced as per Group 2. Group 5 was treated with the standard drug silymarin and diclofenac. Group 6 and Group 7 were given 1 mL and 2 mL of Madhuca longifolia seed oil alone. After the study period, parameters like liver enzyme markers, renal enzyme markers, and antioxidants were measured, and tissue samples were analyzed for histopathological changes. The results proved that pre-treatment of 1 mL ofMadhuca longifolia seed oil has efficacy against diclofenac-induced toxicity.
Page(s): 186-195
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.60(03) [March 2023]

Files in This Item:
File Description SizeFormat 
IJBB-186-195.pdf2.41 MBAdobe PDFView/Open
IJBB-186-195suppl .pdf313.27 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.