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Title: Synthesis and antimicrobial activity of novel benzo[4', 5']-imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e]pyridines
Authors: Prasoona, G
Kishore, B
Brahmeshwari, G
Keywords: 1-(Prop-2-yn-1-yl)-1H-benzo[d]imidazo-2-carbaldehydes;condensation;intramolecular Povarov reaction;benzo[4',5']imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e] pyridines;antimicrobial activity
Issue Date: Feb-2022
Publisher: NIScPR-CSIR, India
Abstract: Synthesis of novel benzo [4',5'] imidazo [1',2':1,2] pyrrolo [3,4-b] isoxazolo [4,5-e] pyridines 8 has been achieved by reaction of 1-(prop-2-yn-1-yl)-1H-benzo [d] imidazo-2-carbaldehydes 5 with 5-amino -3-methylisoxazole 6 in presence of InCl3 in CH3CN media, followed by reaction of imine 7 with BF3.Et2O in DCE at 80°C. The newly synthesized title compounds 8 have been evaluated for their in vitro antimicrobial activity. Compounds 8 exhibit potent antimicrobial activity compared to that of standard drugs.
Page(s): 174-183
ISSN: 2583-1321 (Online); 0019-5103 (Print)
Appears in Collections:IJC Vol.61(02) [February 2022]

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