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http://nopr.niscpr.res.in/handle/123456789/59191| Title: | Synthesis and antimicrobial activity of novel benzo[4', 5']-imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e]pyridines |
| Authors: | Prasoona, G Kishore, B Brahmeshwari, G |
| Keywords: | 1-(Prop-2-yn-1-yl)-1H-benzo[d]imidazo-2-carbaldehydes;condensation;intramolecular Povarov reaction;benzo[4',5']imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e] pyridines;antimicrobial activity |
| Issue Date: | Feb-2022 |
| Publisher: | NIScPR-CSIR, India |
| Abstract: | Synthesis of novel benzo [4',5'] imidazo [1',2':1,2] pyrrolo [3,4-b] isoxazolo [4,5-e] pyridines 8 has been achieved by reaction of 1-(prop-2-yn-1-yl)-1H-benzo [d] imidazo-2-carbaldehydes 5 with 5-amino -3-methylisoxazole 6 in presence of InCl3 in CH3CN media, followed by reaction of imine 7 with BF3.Et2O in DCE at 80°C. The newly synthesized title compounds 8 have been evaluated for their in vitro antimicrobial activity. Compounds 8 exhibit potent antimicrobial activity compared to that of standard drugs. |
| Page(s): | 174-183 |
| ISSN: | 2583-1321 (Online); 0019-5103 (Print) |
| Appears in Collections: | IJC Vol.61(02) [February 2022] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Indian J Chem, 61, 174-183 (Feb,2022).pdf | 627.02 kB | Adobe PDF | View/Open |
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