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Title: Spiro-heterocycles: A convenient synthesis and antimicrobial activity of some 3-(5-aryl/aryloxymethyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1',2-thiazolidin-4-ones
Authors: Begum, Kahkashan
Ahmad, Akeel
Tiwari, Shailendra
Keywords: Substituted aryl/aryloxymethyl;1,3,4-thiadiazole;spiro-cyclohexane;antimicrobial activity;antifungal activity
Issue Date: Nov-2021
Publisher: NIScPR-CSIR, India
Abstract: A new series of novel 3-(5-aryl/aryloxy methyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1'2-thiazolidin-4-ones have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been determined for the test compounds as well as for reference standards. Compounds 3c, 3d, 6c and 6d have shown good antibacterial activity where as compounds 3a, 3b, 6a and 6b have displayed better antifungal activity.
Page(s): 1490-1495
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(11) [November 2021]

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