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Title: Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides
Authors: Gosavi, Kirankumar S
Mahale, Keshao A
Patil, Nilesh S
Patil, Sambhaji V
Keywords: Maleimide;Maleic anhydride;MIC;Antifungal;Antibacterial
Issue Date: Mar-2021
Publisher: NISCAIR-CSIR, India
Abstract: In the present investigation, a series of 3-aryl-4-methoxy N-alkyl maleimide 5a-l have been synthesized and screened for their antimicrobial activity against one Gram positive bacteria (S. aureus), one Gram negative bacteria (E. coli) and fungal strains (C. albicans, C. tropicalis,  A. niger and A. clavatus). The structures of the compounds have been substantiated by their IR, NMR, mass and elemental analysis. The minimum inhibitory concentrations (MICs) of synthesized maleimides have been determined by broth microdilution method. Of the newly synthesized maleimides, compounds 5c, 5f, 5h, 5i, 5k and 5l registered significant activity against the tested microorganisms.
Page(s): 473-478
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(03) [March 2021]

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