Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/5631
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dc.contributor.authorMarikkannu, Rajeshwari-
dc.contributor.authorPalanivelu, P-
dc.date.accessioned2009-07-30T06:02:59Z-
dc.date.available2009-07-30T06:02:59Z-
dc.date.issued2005-01-
dc.identifier.issn0975-0967 (Online); 0972-5849 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/5631-
dc.description21-38en_US
dc.description.abstractMany cis acting elements have been identified in the 3' and 5' untranslated regions (UTRs) of eukaryotic mRNAs. These cis acting elements are found to play vital roles in pre-mRNA processing, nucleo-cytoplasmic transport of processed mRNAs, determining the efficiency of translation of mRNAs and their stability and degradation in the cytoplasm. UTRScan utility has been used to identify these patterns in mRNAs. However, the UTRScan is not very sensitive and also not highly specific. It often generates many false positives as it scans the whole mRNA including the coding sequence. The authors have developed a new algorithm and an Internet based web application tool, named UlTRaSCAN, which overcomes these limitations and proved to be highly specific and sensitive in detecting patterns in UTRs. The new algorithm identifies these cis acting elements only in the 3' and 5' UTRs of eukaryotic mRNA/DNA sequences. The sensitivity is more than doubled and the specificity is increased, close to 100%. The UlTRaSCAN also minimized the false positives to almost 0% and the false negatives to large extent. en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.relation.ispartofseriesInt. Cl.7 C 12 N 15/10; G 06 F 15/00en_US
dc.sourceIJBT Vol.4(1) [January 2005]en_US
dc.subjecteukaryotic mRNAsen_US
dc.subject3' untranslated regionen_US
dc.subject5' untranslated regionen_US
dc.subjectUTRScanen_US
dc.subjectUlTRaSCANen_US
dc.subjectUTR patternsen_US
dc.titleUlTRaSCAN-An algorithm for prediction of pattern(s) in untranslated regions of eukaryotic mRNAsen_US
dc.typeArticleen_US
Appears in Collections:IJBT Vol.04(1) [January 2005]

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