2-Pyridone quinoline hybrids as potent antibacterial and antifungal agents

Abstract

An efficient synthetic strategy for the synthesis of 6-amino-1-(((2-chloroquinolin-3-yl)methylene)amino)-2-oxo-4-(aryl)-1,2-dihydropyridine-3,5-dicarbonitriles is well described in this paper. Structures of synthesized compounds have been identified by standard spectroscopic techniques like ¹H NMR, ¹³C NMR, IR and mass spectroscopy. Results of the biological activity reveals that electron withdrawing groups and presence of –OH group on <em>meta</em> position play a significant role for the increment in the antibacterial and antifungal activities respectively of <strong>3a-j</strong>. In the present study, it has been observed that compounds <strong>3i</strong> and <strong>3e</strong> are the most active antimicrobials.