A convenient synthesis and biological activities of N-(pyridin-3-ylmethylene) benzohydrazides by the condensation of nicotinaldehydes with benzohydrazides

Abstract

Series of <em>N</em>'-(pyridine-3-ylmethylene)benzohydrazides <strong>3a-y</strong> have been prepared by the condensation of nicotinaldehydes <strong>1a-e</strong> with benzohydrazides <strong>2a-e</strong> in the presence of glacial AcOH in ethanol at room temperature. Total twenty five compounds have been prepared and confirmed based on spectral data. The compounds have been evaluated for anti-microbial, free radical scavenging (DPPH, ABTS^.+) and α-glucosidase inhibitory activities. Compound <strong>3h</strong> has shown potent anti-fungal activity. Compounds <strong>3f-g</strong> and <strong>3j</strong> have shown potent ABTS^.+ free radical scavenging activity. Compound <strong>3d</strong> has shown potent anti-hyperglycemic activity.