Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/5523
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSingh, Neera-
dc.contributor.authorGupta, Manushma-
dc.date.accessioned2009-07-23T10:46:42Z-
dc.date.available2009-07-23T10:46:42Z-
dc.date.issued2007-12-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/5523-
dc.description1055-1062en_US
dc.description.abstractAcetone extract of whole fruit powder of M. charantia (bitter gourd) in doses 25, 50 and 75 mg/100 g body weight lowered the blood glucose from 13.30 to 50% after 8 to 30 days treatment in alloxan diabetic albino rats, confirming antihyperglycemic effect of this plant in diabetic animals and humans. Histological observations with acetone extract showed different phases of recovery of β cells of the islets of Langerhans of pancreas, which in the untreated diabetic rats were less in number and showed varied degree of atrophy. The most important finding of the present study was observation of the presence of small scattered islets among the acinar tissue in some experimental animals, which may reflect neoformation of islets from pre-existing islet cells. The liver of alloxan diabetic rats showed hydropic degeneration, fatty change and necrosis at some places but liver of extract treated animals was normal. Glycogen localization in liver of diabetic rats was faint but after 30 days treatment with different doses of extract, normal to heavy glycogen localization was observed.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJEB Vol.45(12) [December 2007]en_US
dc.subjectAcetone extracten_US
dc.subjectAlloxan diabetesen_US
dc.subjectβ cellsen_US
dc.subjectMomordica charantiaen_US
dc.subjectRegenerationen_US
dc.titleRegeneration of β cells in islets of Langerhans of pancreas of alloxan diabetic rats by acetone extract of Momordica charantia (Linn.) (bitter gourd) fruitsen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.45(12) [December 2007]

Files in This Item:
File Description SizeFormat 
IJEB 45(12) 1055-1062.pdf2.27 MBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.