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Title: Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents
Authors: Prasoona, G
Kishore, B
Brahmeshwari, G
Keywords: Multi-component reaction;Benzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles;Cyclization;Benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidines;Antimicrobial activity
Issue Date: Apr-2020
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d] pyrimidines 5/6 has been achieved by reaction of 2-amino-4-aryl-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles 4 with formaldehyde/urea. The key intermediate 4, is obtained by reaction of 2-aminobenzaldehyde 1 with aromatic aldehyde and malononitrile by a three-component one-pot process. The newly synthesized title compounds 5/6 have been evaluated for their in vitro antimicrobial activity. Compounds 5 and 6 exhibit potent antimicrobial activity compared to that of standard drugs.
Page(s): 445-453
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(04) [April 2020]

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