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http://nopr.niscpr.res.in/handle/123456789/54367| Title: | Investigation of Growth Inhibitory Effects of cyclo (Nα-pyrido)-bis-[(L-valinyl)-L-ornthenyl acid hydrazide] on Various Cancer Cells as well as in vitro VEGFR-2 Kinase Inhibition |
| Authors: | Amr, A E Elsayed, E A Al-Omar, M A El-Enshasy, H A |
| Keywords: | Azide method;Macrocyclic tripeptidopyridine;Cell lines;In vivo;In vitro;Kinase activity |
| Issue Date: | Apr-2020 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | During the current work, we synthesized a new peptide derivative; 4,13-diisopropyl-2,5,12,15-tetraoxo-3,6,11,14-tetraaza-1(3,5)-pyridinacyclopentadecaphane-7-carbohydrazide. The prepared hydrazide was investigated for its in vivo as well as in vitro anticancer effects. Results revealed that this derivative has a great potential against 6 cancerous cell lines. Furthermore, the highest effect was obtained against HT1080 and HeLa cells, where the compound showed 7.4- and 15.1-folds increased activity against them, respectively. Additionally, the compound seems to exert its potential anticancer effect by affecting the kinase enzyme VEGFR-2. Finally, the compound showed promising results when tested in in vivo against prostate cancer developed animal models. |
| Page(s): | 328–332 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Appears in Collections: | JSIR Vol.79(04) [April 2020] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JSIR 79(4) 328-332.pdf | 316.62 kB | Adobe PDF | View/Open |
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