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dc.contributor.authorRao, RS-
dc.contributor.authorPrakash, A-
dc.contributor.authorMedhi, B-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractEpilepsy is a common health problem. Although variety of factors influence the incidence and prevalence of seizures, cytokines are considered to play an important role in seizures. Cytokines are also known to be involved in other neurodegenerative disorders. Proinflammatory cytokines like IL-1, IL-6, TNF- and growth factor vascular endothelial growth factor (VEGF) as well as anti-inflammatory cytokine IL-10 and related molecules have been described in CNS and plasma of experimental models of seizures and clinical cases of epilepsy. There are reports suggesting more predispositions to seizures during inflammatory conditions like colitis, pneumonia and rheumatoid arthritis. These inflammatory cytokines and growth factors are also known to have dual roles in affecting seizure susceptibility. It remains to be seen if cytokine modulators can be therapeutically exploited for patients with inflammatory disorder and suffering from epilepsy.en_US
dc.sourceIJEB Vol.47(08) [August 2009]en_US
dc.subjectAntiepileptic drugsen_US
dc.titleRole of different cytokines and seizure susceptibility: A new dimension towards epilepsy researchen_US
Appears in Collections:IJEB Vol.47(08) [August 2009]

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