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Title: Cocos nucifera L. inflorescence extract: An effective hepatoprotective agent
Authors: Chithra, Manikantan Ambika
Ijinu, Thadiyan Parambil
Kharkwal, Harsha
Sharma, Rajeev Kumar
Janardhanan, Kainoor Krishnankutty
Pushpangadan, Palpu
George, Varughese
Keywords: Cocos nucifera inflorescence;Hepatoprotective effect;Phenolic content
Issue Date: Jan-2020
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.20: A01N 33/14, A61P 1/16, C08K 5/138
Abstract: The flowering inflorescence of Cocos nucifera, a main constituent of several traditional drug formulations was investigated with a view to study the effect of the acetone extract of C. nucifera inflorescence (CnAE) on acetaminophen-induced hepatotoxicity. The total phenol and flavonoid contents of the extract are found to be 222.6 µg gallic acid equivalent/g and 120.8 µg quercetin equivalent/g, respectively. The LD50 value was >5000 mg/kg b.w. The antioxidant activity was assessed using three methods, namely, 2,2’- diphenyl-1-picryl hydrazyl assay, 2,2’-azinobis (3-ethylbenzthiazoline-6-sulphonic acid) assay and ferric reducing antioxidant power assay and the IC50 values were found to be 65.72, 66.94 and 89.84 μg/mL, respectively. Effect of CnAE (100, 200 and 400 mg/kg b.w.) and silymarin (100 mg/kg b.w.) against acetaminophen-induced liver toxicity was evaluated in Wistar rats. The study showed that CnAE pre-treated groups remarkably prevented the increase in serum alanine amino transferase, aspartate amino transferase and alkaline phosphatase level and decrease in the level of liver superoxide dismutase, reduced glutathione, glutathione-S-transferase and glutathione peroxidise. The extract also suppressed the elevated level of malondialdehyde. The biochemical determinations supported the histopathological examination and blood parameter findings. The findings of our study indicated that the phenolic-rich CnAE could be an interesting alternative candidate against acetaminophen-induced hepato-toxicity and associated oxidative stress.
Page(s): 128-136
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.19(1) [January 2020]

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