Synthesis and anti-microbial activity of 2H-chromenylmethylene benzohydrazides

Abstract

2<em>H</em>-Chromenylmethylene benzohydrazides <strong>6a-t</strong> have been prepared by the reaction of 2<em>H</em>-chromene-3-carbaldehydes <strong>4a-e</strong> with benzohydrizides <strong>5a-c </strong>and isonicotinohydrazide <strong>5d</strong> in ethyl alcohol at room temperature. All the synthesized compounds have been evaluated for their anti-microbial activity. Compounds <strong>6a</strong>, <strong>6f</strong>, <strong>6p </strong>and <strong>6t</strong> have potent anti-bacterial activity. Compounds <strong>6a </strong>and <strong>6f </strong>are highly potent and <strong>6l</strong>, <strong>6p </strong>and <strong>6t</strong> have equi potent anti-fungal activity.