Synthesis, characterization and antibacterial screening of fluorinated benzofuran containing heterocycles

Abstract

2-(4-Fluorophenyl)-5-phenylbenzofuran-3-carboxylic acid <strong>1 </strong>when treated with substituted 2-hydroxyacetophenones <strong>2</strong> in dry pyridine and POCl₃ affords compound <strong>3</strong> which when reacted with pyridine/KOH by B. V. transformation gives <strong>4</strong>. Compound <strong>4</strong> on refluxing with different reagents Ac₂O in presence of sodium acetate, acetic acid in HCl, and hydrazinehydrate in alcohol gives <strong>5</strong>, <strong>6</strong> and <strong>7</strong> respectively. The structures of all synthesized compounds have been confirmed by spectroscopic techniques. All the synthesized compounds have been screened for their antibacterial activity.