Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/45931
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Marri, Srinivas | - |
dc.contributor.author | Kakkerla, Ramu | - |
dc.contributor.author | Krishna, M P S Murali | - |
dc.date.accessioned | 2019-03-11T05:00:40Z | - |
dc.date.available | 2019-03-11T05:00:40Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 0975-0983(Online); 0376-4699(Print) | - |
dc.identifier.uri | http://nopr.niscair.res.in/handle/123456789/45931 | - |
dc.description | 381-386 | en_US |
dc.description.abstract | A new series of 4-aryl-3-chloro-1-(3,5-dimethyl-isoxazol-4-yl)-azetidin-2-ones 4 have been prepared from 4-amino-3,5-dimethylisoxazole 1. Compound 1 on treatment with aromatic aldehydes 2a-i furnishes the Schiff bases 3a-i, which are then reacted with chloroacetyl chloride in presence of triethyl amine to afford the title compounds viz., isoxazolyl azetidin-2-ones 4a-i. The structures of β-lactams 4a-i have been confirmed by IR, 1H and 13C NMR and mass spectral data. QSRT studies have been performed, and the compounds 4a-ihave been evaluated for their in vitro antibacterial activity. Compounds 4b, 4c and 4d exhibited promising antibacterial activity. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NISCAIR-CSIR, India | en_US |
dc.rights | ![]() | en_US |
dc.source | IJC-B Vol.58B(03) [March 2019] | en_US |
dc.subject | Isoxazolyl azetidin-2-ones | en_US |
dc.subject | Schiff base | en_US |
dc.subject | Cycloaddition | en_US |
dc.subject | QSRT studies | en_US |
dc.subject | Antibacterial activity | en_US |
dc.title | Synthesis, QSRT studies and antibacterial activity of 4-aryl-3-chloro-1-(3,5-dimethyl-isoxazol-4-yl)-azetidin-2-ones | en_US |
dc.type | Article | en_US |
Appears in Collections: | IJC-B Vol.58B(03) [March 2019] |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IJCB 58B(3) 381-386.pdf | 292.46 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.