Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/45931
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dc.contributor.authorMarri, Srinivas-
dc.contributor.authorKakkerla, Ramu-
dc.contributor.authorKrishna, M P S Murali-
dc.date.accessioned2019-03-11T05:00:40Z-
dc.date.available2019-03-11T05:00:40Z-
dc.date.issued2019-03-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/45931-
dc.description381-386en_US
dc.description.abstractA new series of 4-aryl-3-chloro-1-(3,5-dimethyl-isoxazol-4-yl)-azetidin-2-ones 4 have been prepared from 4-amino-3,5-dimethylisoxazole 1. Compound 1 on treatment with aromatic aldehydes 2a-i furnishes the Schiff bases 3a-i, which are then reacted with chloroacetyl chloride in presence of triethyl amine to afford the title compounds viz., isoxazolyl azetidin-2-ones 4a-i. The structures of β-lactams 4a-i have been confirmed by IR, 1H and 13C NMR and mass spectral data. QSRT studies have been performed, and the compounds 4a-ihave been evaluated for their in vitro antibacterial activity. Compounds 4b, 4c and 4d exhibited promising antibacterial activity.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.58B(03) [March 2019]en_US
dc.subjectIsoxazolyl azetidin-2-onesen_US
dc.subjectSchiff baseen_US
dc.subjectCycloadditionen_US
dc.subjectQSRT studiesen_US
dc.subjectAntibacterial activityen_US
dc.titleSynthesis, QSRT studies and antibacterial activity of 4-aryl-3-chloro-1-(3,5-dimethyl-isoxazol-4-yl)-azetidin-2-onesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.58B(03) [March 2019]

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