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Title: In silico interaction of catechin with some immunomodulatory targets: A docking analysis
Authors: Ganeshpurkar, Aditya
Saluja, Ajay
Keywords: Catechin;Immunomodulatory agent;Inflammation;Cytokines;Nitric oxide
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
Abstract: The use of plant products as immunomodulator has a long history. For eternal era, plant, mineral and animal products are used as drugs for the treatment of various diseases. The present-day synthetic compounds find their leads in natural products. The process of immunomodulation amends the immune system of an individual by prying with its usual functions. Research of immunomodulators from natural sources has been extensively studied for modulation of immune system along with protection and prevention of diseases. Catechin, a flavonoid has been investigated for its potential anti-inflammatory effects. Analgesic effects have been observed for catechin in experimental animals. The present study is focused on exploring the in silico interaction of catechin with some chemokines and inflammatory targets. In this study, catechin was docked with tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2). Docking studies revealed the interaction of catechin with these targets. The result of present study provides insight for the discovery of novel molecules for immunomodulation and treatment of inflammatory disorders. Findings from the present study show that catechin interact with several chemokines and inflammatory mediators. Further studies quantitative structure activity relationship and quantitative structure property relationship on catechin and associated flavonoids are necessary to develop and establish studies which may serve a stepping stone for the development of novel and safe immunomodulator. Catechin, can, therefore, can be considered as a candidate for development of an immunomodulatory agent.
Page(s): 626-631
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.17(4) [October 2018]

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