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Title: Synthesis of some new condensed heterocyclic 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of 2-naphthoxyacetic acid as potent anti-inflammatory agents with reduced ulcerogenicity
Authors: Amir, Mohd
Akhter, Md Wasim
Haq, S Ehtaishamul
Keywords: Triazolo-thiadiazole;Anti-inflammatory;Ulcerogenicity;Lipid peroxidation;Hepatotoxic;Histopathological studies
Issue Date: Nov-2017
Publisher: NISCAIR-CSIR, India
Abstract: A series of triazolo-thiadiazole derivatives have been synthesized from 2-naphthoxyacetic acid and evaluated for their anti-inflammatory and analgesic activity. Compounds which show good anti-inflammatory activity in comparision to standard drug naproxen have been further evaluated for their ulcerogenic and lipid peroxidation activity. The compounds  6-(2-chlorophenyl)-3-[(naphthalen-2-yloxy)methyl]-[1,2,4]triazolo[3,4-b] [1,3,4] thiadiazole 3b and 6 - (2,4-dichlorophenyl)-3-[(naphthalene -2-yloxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 3c show maximum anti-inflammatory activity with reduced ulcerogenic potential and have also been evaluated for their hepatotoxicity and histopathological characteristics.
Page(s): 1177-1184
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(11) [November 2017]

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