Synthesis of some new condensed heterocyclic 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of 2-naphthoxyacetic acid as potent anti-inflammatory agents with reduced ulcerogenicity

Abstract

A series of triazolo-thiadiazole derivatives have been synthesized from 2-naphthoxyacetic acid and evaluated for their anti-inflammatory and analgesic activity. Compounds which show good anti-inflammatory activity in comparision to standard drug naproxen have been further evaluated for their ulcerogenic and lipid peroxidation activity. The compounds 6-(2-chlorophenyl)-3-[(naphthalen-2-yloxy)methyl]-[1,2,4]triazolo[3,4-b] [1,3,4] thiadiazole <strong>3b</strong> and 6 - (2,4-dichlorophenyl)-3-[(naphthalene -2-yloxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole <strong>3c</strong> show maximum anti-inflammatory activity with reduced ulcerogenic potential and have also been evaluated for their hepatotoxicity and histopathological characteristics.