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|Title:||PEG-400 mediated and promoted eco-friendly one-pot synthesis of isoxazolyl pyridines, quinolines and 3-hydroxy-2-oxoindoles through sp3 C-H bond functionalization of methyl aza-arenes|
|Keywords:||C-H activation;Michael addition;Isoxazole;Azaarene;Isatin|
|Abstract:||Polyethylene glycol (PEG) promoted functionalization of sp3 C-H bonds of methyl aza -arenes with 3-methyl-4-nitro-5-styrylisoxazoles for construction of isoxazolyl pyridines 3 and quinolines 5 is described. Nitrostyrylisoxazoles are proved to be good C=C elctrophilic acceptors for the construction of various azaarene-containing Michael addition products. Functionalization of sp3 C-H bonds of 3,5-dimethyl-4-nitroisoxazole is also described for synthesis of biologically active isoxazolyl 3-hydroxy-2-oxoindoles 8.|
|Appears in Collections:||IJC-B Vol.56B(11) [November 2017]|
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