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dc.contributor.authorDesai, N C-
dc.contributor.authorHarsora, J P-
dc.contributor.authorPatel, B Y-
dc.contributor.authorJadeja, K A-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractTwo biologically potential nitrogen heterocycles quinoline and 2-pyridone have been incorporated to synthesize imine series of 6-amino-1-((2,6-dichloroquinolin-3-yl)methyleneamino)-4-(aryl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles (3a-m). IR, 1H and 13C NMR, and mass spectrometry have accomplished structural evaluation. All these compounds have been screened for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes as well as antifungal activity against Candida albicans, Aspergillus niger and Aspergillus clavatus. From the screened results, it has been observed that the compounds 3b and 3c are found to have excellent activity against bacterial strains whereas compound 3f has unveiled excellent activity against fungal strains. SAR study has revealed that para and meta positions with electron donating functionality are promising sites for antibacterial and antifungal properties respectively.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.56B(09) [September 2017]en_US
dc.subjectNitrogen heterocyclesen_US
dc.subjectAntibacterial activityen_US
dc.subjectAntifungal activityen_US
dc.titleSynthesis of a novel series of imines containing nitrogen heterocycles as promising antibacterial and antifungal agentsen_US
Appears in Collections:IJC-B Vol.56B(09) [September 2017]

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