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http://nopr.niscpr.res.in/handle/123456789/42363| Title: | Total synthesis of (−)-Sachalinol A and evaluation of its cytotoxicity |
| Authors: | Satyavani, T Vyshnavi, Yelchuri Karuna, Mallampalli Sri Lakshmi Prasad, Rachapudi Badari Narayana Sujitha, P Kumar, C Ganesh |
| Keywords: | Anticancer;(−)-Sachalinol A;Cytotoxicity;Monoterpenoids;Sharpless epoxidation;Riley oxidationanhyd |
| Issue Date: | Jul-2017 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | (-)-Sachalinol A, a group of monoterpenoids, oxygenated derivatives of rosinidol, has been synthesized employing a simple, eight step procedure. The compound demonstrates excellent cytotoxicity against MDA-MB-231 derived from human breast adenocarcinoma cells (ATCC No. HTB-26) and HeLa derived from human cervical cancer cells (ATCC No. CCL-2). Good activity is observed against A549 derived from human alveolar adenocarcinoma epithelial cells (ATCC No. CCL-185) and Neuro2a derived from mouse neuroblastoma cells (ATCC No. CCL-131). Moderate activity is also observed against MCF-7 derived from human breast adenocarcinoma cells (ATCC No. HTB-22). |
| Page(s): | 695-700 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.56B(07) [July 2017] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 56B(7) 695-700.pdf | Main article | 609.64 kB | Adobe PDF | View/Open |
| IJCB 56B(7) 695-700_Suppl Data.pdf | Supplementary Data | 49.97 kB | Adobe PDF | View/Open |
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