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Title: Total synthesis of (−)-Sachalinol A and evaluation of its cytotoxicity
Authors: Satyavani, T
Vyshnavi, Yelchuri
Karuna, Mallampalli Sri Lakshmi
Prasad, Rachapudi Badari Narayana
Sujitha, P
Kumar, C Ganesh
Keywords: Anticancer;(−)-Sachalinol A;Cytotoxicity;Monoterpenoids;Sharpless epoxidation;Riley oxidationanhyd
Issue Date: Jul-2017
Publisher: NISCAIR-CSIR, India
Abstract: (-)-Sachalinol A, a group of monoterpenoids, oxygenated derivatives of rosinidol, has been synthesized employing a simple, eight step procedure. The compound demonstrates excellent cytotoxicity against MDA-MB-231 derived from human breast adenocarcinoma cells (ATCC No. HTB-26) and HeLa derived from human cervical cancer cells (ATCC No. CCL-2). Good activity is observed against A549 derived from human alveolar adenocarcinoma epithelial cells (ATCC No. CCL-185) and Neuro2a derived from mouse neuroblastoma cells (ATCC No. CCL-131). Moderate activity is also observed against MCF-7 derived from human breast adenocarcinoma cells (ATCC No. HTB-22).
Page(s): 695-700
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(07) [July 2017]

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