Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSathishkumar, S-
dc.contributor.authorKavitha, Helen P-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractIn this paper, has been described the synthesis of some novel tetrazolodiazepine derivatives starting from piperidin-4-ones, with a view to test the novel compounds for various biological activities. The structures of the synthesized compounds have been established by IR, 1H and 13C NMR, mass and elemental analysis. Representative compounds have been characterized by COSY, HETCOR and DEPT 135 spectra. The representative compounds of the tetrazolodiazepine have been tested for anti-inflammatory activity by carrageenan induced paw edema method. From the results of the in vivo study, it is observed that the compounds taken for the study possess fairly good activity. Among the synthesized compounds, 6,8-bis-(3-chlorophenyl)-5-methyl-6,7,8,9-tetrahydro-5H-tetrazolo[1,5-d][1,4]diazepine 3c shows potent anti-inflammatory activity.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.56B(07) [July 2017]en_US
dc.subjectTwo dimensional NMR studiesen_US
dc.subjectAnti-inflammatory activityen_US
dc.titleSynthesis, characterization and anti-inflammatory evaluation of novel substituted tetrazolodiazepine derivativesen_US
Appears in Collections:IJC-B Vol.56B(07) [July 2017]

Files in This Item:
File Description SizeFormat 
IJCB 56B(7) 732-739.pdf208.41 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.