Synthesis, characterization and anti-inflammatory evaluation of novel substituted tetrazolodiazepine derivatives

Abstract

In this paper, has been described the synthesis of some novel tetrazolodiazepine derivatives starting from piperidin-4-ones, with a view to test the novel compounds for various biological activities. The structures of the synthesized compounds have been established by IR, ¹H and ¹³C NMR, mass and elemental analysis. Representative compounds have been characterized by COSY, HETCOR and DEPT 135 spectra. The representative compounds of the tetrazolodiazepine have been tested for anti-inflammatory activity by carrageenan induced paw edema method. From the results of the <i>in vivo</i> study, it is observed that the compounds taken for the study possess fairly good activity. Among the synthesized compounds, 6,8-bis-(3-chlorophenyl)-5-methyl-6,7,8,9-tetrahydro-5<i>H</i>-tetrazolo[1,5-<i>d</i>][1,4]diazepine <b>3c</b> shows potent anti-inflammatory activity.