Synthesis and crystal structures of pyridine- 2-carboxaldehyde thiosemicarbazone, its mononuclear and cytotoxic Cu(II) and polynuclear Pb(II) complexes: Effect of size of metal ion on nucleation of the complexes

Abstract

Synthesis and X-ray structural characterization of pyridine-2-carboxaldehyde thiosemicarbazone (<b>L</b>), and its metal complexes, [Cu(<b>L</b>)(OH₂)](ClO₄)₂ and [Pb(<b>L</b>)(ONO₂)₂]_n are reported. X-ray diffraction reveals that the metal centres in the two complexes are distorted square planar and square pyramid geometries, respectively. Among the three compounds [Cu(<b>L</b>)(OH₂)](ClO₄)₂ is found to be active against human keratinocyte cell line.