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Title: Hypervalent iodine mediated solid state synthesis and biological activity of some new 1-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]-3-(4-nitrophenyl)- 1,2-dihydro [1,8]naphthyridin-2-ones
Authors: Mogilaiah, K
Prasad, D Hari
Rao, A Nageswara
Jyothi, S
Babu, H Ramesh
Keywords: 1,3,4-Oxadiazole;1,8-naphthyridine;Iodobenzene diacetate (IBD);Solid state;Antibacterial activity;Anti-inflammatory activity
Issue Date: Jun-2017
Publisher: NISCAIR-CSIR, India
Abstract: A convenient and eco-friendly protocol has been described for the synthesis of 1-[(5-aryl-1,3,4-oxadiazol-2-yl)-methyl]-3-(4-nitro-phenyl)-1,2-dihydro[1,8]naphthyridin-2-ones 5 by the oxidation of the corresponding Nʹ1-arylmethylene-2-[3-(4-nitro-phenyl)-2-oxo-1,2-dihydro[1,8]naphthyridin-1-yl]-ethanohydrazides 4 with iodobenzene diacetate (IBD) in the solid state at RT under grinding conditions. The products are obtained in good yields and excellent purities. The structures of the compounds 2-5 have been established by theirspectral (IR, 1H NMR and MS) and analytic data. The compounds 5 have been evaluated for their antibacterial and anti-inflammatory activities.
Page(s): 656-662
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(06) [June 2017]

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