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Title: Green synthesis, antibacterial and anti-inflammatory activities of 2-(2-substituted[1,8]naphthyridin-3-yl)-5-(substituted-2-thienyl)-1,3,4-oxadiazoles
Authors: Mogilaiah, K
Venkanna, Ch
Rao, A Nageswara
Babu, H Ramesh
Keywords: 1,8-Naphthyridines;1,3,4-oxadiazoles;Iodobenzene diacetate[ PhI(OAc)2] solid state;Antibacterial activity;Anti-inflammatory activity
Issue Date: Jun-2017
Publisher: NISCAIR-CSIR, India
Abstract: An efficient and mild method for the synthesis of 2-(2-substituted[1,8]naphthyridin-3-yl)-5-(substituted-2-thienyl)-1,3,4-oxadiazoles 4 is reported by the oxidation of the corresponding Nʹ3-[1-(substituted-2-thienyl)methylidene]-2-sustituted[1,8]naphthyridine-3-carbohydrazides 3 with iodobenzene diacetate(PhI(OAc)2] in solid state. The reaction proceeds efficiently giving the products in good yields and excellent purities. The structural assignments of compounds 3 and 4 are based on their elemental analyses andspectral (IR, 1H NMR and MS) data. The compounds 4 have been screened for their antibacterial and anti-inflammatory activities.
Page(s): 670-676
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(06) [June 2017]

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