Lipid profile changes in mouse gastrocnemius muscle after denervation and beta-adrenoceptor stimulation

Abstract

Denervation results in the accumulation of total lipids (94.68%), phospholipids (190.94%), cholesterol (31.82%) and triglycerides (30.86%) within 30 days in gastrocnemius muscle of adult mice. The treatment of denervated mice with β-agonist isoproterenol (60 mg kg^-1 day^-1 for 30 days, orally) does not inhibit the increased lipid biosynthesis induced by the loss of neural supply to gastrocnemius muscle. The denervated gastrocnemius muscle shows 61.87, 133.14, 40.27 and 16.46% more total lipids, phospholipid, cholesterol and triglyceride contents respectively as compared to normal innervated muscles even after the drug administration but it maintains significantly low levels of lipids as compared to untreated denervated mice.