Please use this identifier to cite or link to this item:
Title: Synthesis and biological evaluation of some new N-fatty acyl derivatives of 4,5-dimethoxy tryptamine
Authors: Venepally, Vijayendar
Prasad, R B N
Poornachandra, Y
Kumar, C Ganesh
Jala, Ram Chandra Reddy
Keywords: Anticancer;Antioxidant;Antimicrobial;Tryptamine;DPPH radical scavenging;Super oxide free radical scavenging;Lipid peroxidation;BHT
Issue Date: May-2017
Publisher: NISCAIR-CSIR, India
Abstract: The aim of this study is to synthesize and examine the in vitro anticancer, antioxidant and antimicrobial activities of N-fatty acyl derivatives of 4,5-dimethoxy tryptamine. A series of new N-fatty acyl derivatives of 4,5-dimethoxy tryptamine compounds derived from 2,3-dimethoxy benzaldehyde have been prepared. The synthesized compounds have been characterized and screened for anticancer, antioxidant and antimicrobial activities. The synthesized derivatives have been evaluated for their cytotoxicity on various cell lines. Compounds 9a and 9g have shown promising cytotoxicity, while compounds 9c, 9d and 9e have shown moderate activity for all the tested cancer cell lines. The antioxidant activities have been determined with regard to DPPH radical scavenging activity, superoxide free radical scavenging activity and inhibition of lipid peroxidation. Based on the results, it has been observed that N-fatty acyl derivatives of 4,5-dimethoxy tryptamine exhibit promising antioxidant activity. In particular, the undecenoic acid-based derivative 9d shows good antioxidant activity in all the three assays. Further, the compound 9d exhibits significant antimicrobial activity against Bacillus subtilis MTCC 121 with MIC value of 15.6 µg/mL.
Page(s): 531-541
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(05) [May 2017]

Files in This Item:
File Description SizeFormat 
IJCB 56B(5) 531-541.pdfMain Article310.96 kBAdobe PDFView/Open
IJCB 56B(5) 531-541_Suppl Data.pdfSupplementary Data2.67 MBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.