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Title: Synthesis and antimicrobial studies of 1,2,3,4-tetrahydropyrimidine bearing imidazole analogues
Authors: Desai, N C
Vaghani, H V
Karkar, T J
Patel, B Y
Jadeja, K A
Keywords: 1,2,3,4-Tetrahydropyrimidine;Imidazole;Antimicrobial activity;MIC;SAR studies
Issue Date: Apr-2017
Publisher: NISCAIR-CSIR, India
Abstract: The present paper deals with synthesis of 1,2,3,4-tetrahydropyrimidine bearing an imidazole nucleus which has been synthesized in excellent yields via multi-component Biginelli reaction. The title compounds have been elucidated by IR, 1H and 13C NMR, mass spectrometry and elemental analysis (CHN). Antimicrobial screening of compounds 5a-l have been carried out against Gram-positive (S. aureus, S. pyogenes) and Gram negative bacteria (E. coli, P. aeruginosa) and fungi (C. albicans, A. niger, A. clavatus) using serial broth dilution method with ‘ciprofloxacin’ and ‘griseofulvin’ as standard drugs. Among all screened results, compounds 5e, 5k and 5l are proved to have good anti-bacterial activity and compounds 5e and 5l have good anti-fungal activity. On the basis of SAR studies, it is observed that the existence of electron donating groups at ortho and para position on phenyl ring in compounds 5e, 5k and 5l result in higher antimicrobial activity.
Page(s): 438-446
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(04) [April 2017]

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