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dc.contributor.authorKumar, Ajay-
dc.contributor.authorSingh, Amarjit-
dc.contributor.authorKumar, Rajesh-
dc.contributor.authorPrasad, Ashok K-
dc.contributor.authorParmar, Virinder S-
dc.contributor.authorTararov, Vitali I-
dc.contributor.authorBelokon, Yuri N-
dc.contributor.authorSingh, Sanjay K-
dc.contributor.authorWengel, Jesper-
dc.identifier.issn0975-0975(Online); 0376-4710(Print)-
dc.description.abstractSeventeen noveI 3’-alkylthio-2’,3’-dideoxynucleosides have been synthesised by Michael-type addition of alkylthiols to an ,α,β-unsaturated hexose aldehyde, followed by acetylation, nucleoside coupling and deprotection. Based on these results, a general scheme for combinatorial synthesis of libraries of 3’-substituted 2’,3’-dideoxynucleosides has been proposed. Porcine pancreatic lipase (PPL) has been found to hydrolyse the amides of polyacetoxyaromatic carboxylic acids in a highly chemoselective fashion. The enzyme exclusively hydrolyses the ester group over the amide group. Hydrolysis of diethyl acetamidomalonate in phosphate buffer in the presence of α-chymotrypsin proceeds enantioselectively affording the (+)-monoacid.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-A Vol.36A(06) [June 1997]en_US
dc.titleCombinatorial approach towards synthesis of 2',3'-dideoxynucleosides and enzyme-catalysed selective hydrolysis of diethyl acetamidomalonate and amides of polyacetoxy aromatic carboxylic aciden_US
Appears in Collections:IJC-A Vol.36A(06) [June 1997]

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