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Title: Synthesis of 9-aryl-6-(4-trifluoromethylphenyl)-1,2,4-triazolo[4,3-a] [1,8]naphthyridines using Cu(OAc)2 under microwave irradiation and their antibacterial activity
Authors: Mogilaiah, K
Kumar, K Shiva
Rao, A Nageswara
Babu, H Ramesh
Keywords: 1,2,4-Triazole;1,8-naphthyridine;Cu(OAc)2;Microwave irradiation;Antibacterial activity
Issue Date: Feb-2017
Publisher: NISCAIR-CSIR, India
Abstract: An effective, practical and simple approach towards the synthesis of 9-aryl-6-(4-trifluoromethylphenyl)-1,2,4-triazolo [4,3-a]-[1,8]naphthyridines 8 from the corresponding aryl aldehyde 3-(4-trifluoromethylphenyl)-1,8-naphthyridin-2-ylhydrazones 7 has been achieved, using Cu(OAc)2 in combination with microwave irradiation. The products are obtained in good yields and in a state of high purity. The structural assignments of compounds 3-8 are based on their elemental analyses and spectral (IR, 1H NMR and mass spectroscopy) data. The compounds 8 have been screened for their antibacterial activity.
Page(s): 171-176
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(02) [February 2017]

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