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Title: Synthesis, characterization and antibacterial activity of (E)-4-((3-methyl-4-(methylsulfonyl)pyridin-2-yl)methoxy)-N'-(substitutedbenzylidene)benzohydrazide derivatives
Authors: Saidugari, Swamy
Rao, Lakshmana
Vidya, K
Ram, B
Balram, B
Keywords: Antibacterial activity;4-hydroxybenzoic acid;Synthesis
Issue Date: Feb-2017
Publisher: NISCAIR-CSIR, India
Abstract: Prompted by the various biological and pharmaceutical importance of hydrazone derivatives, herein are reported the synthesis and antibacterial activity of some new benzohydrazide derivatives 6a-n from commercially available 4-hydroxybenzoic acid and 2-chloromethyl-4-methanesulfonyl-3-methylpyridine as starting materials. These compounds have been sufficiently characterized by 1H NMR, mass and IR spectroscopic techniques and evaluated for antibacterial activity. The compounds 6e (R=4-SO2CH3), 6f (R=4-F), 6g (R=4-OCF3), 6h (R=4-CF3), 6i (R=3,4-difluoro) and 6j (R=2,4 difluoro) have shown good activity (ZI: 19-25 mm) against the tested bacterial pathogens viz., Escheria coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococus pyogenes.
Page(s): 177-182
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(02) [February 2017]

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