Synthesis, characterization and antibacterial activity of (<i>E</i>)-4-((3-methyl-4-(methylsulfonyl)pyridin-2-yl)methoxy)-N'-(substitutedbenzylidene)benzohydrazide derivatives

Abstract

Prompted by the various biological and pharmaceutical importance of hydrazone derivatives, herein are reported the synthesis and antibacterial activity of some new benzohydrazide derivatives <b>6a-n</b> from commercially available 4-hydroxybenzoic acid and 2-chloromethyl-4-methanesulfonyl-3-methylpyridine as starting materials. These compounds have been sufficiently characterized by ¹H NMR, mass and IR spectroscopic techniques and evaluated for antibacterial activity. The compounds <b>6e</b> (R=4-SO₂CH₃), <b>6f</b> (R=4-F), <b>6g</b> (R=4-OCF₃), <b>6h</b> (R=4-CF₃), <b>6i</b> (R=3,4-difluoro) and <b>6j</b> (R=2,4 difluoro) have shown good activity (ZI: 19-25 mm) against the tested bacterial pathogens <i>viz</i>., <i>Escheria coli</i>, <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus aureus </i> and <i>Streptococus pyogenes</i>.