Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/39726
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dc.contributor.authorKumar, Singam Naveen-
dc.contributor.authorSadhu, Partha Sarathi-
dc.contributor.authorSharma, Kirti Kumari-
dc.contributor.authorPica-Mattoccia, Livia-
dc.contributor.authorBasso, Annalisa-
dc.contributor.authorCioli, Donato-
dc.contributor.authorRao, Vaidya Jayathirtha-
dc.date.accessioned2017-01-11T09:39:13Z-
dc.date.available2017-01-11T09:39:13Z-
dc.date.issued2017-01-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/39726-
dc.description112-119en_US
dc.description.abstractA series of new furoxan derivatives of praziquantel have been synthesized and evaluated for antischistosomal activity. The newly synthesized hybrid compounds have structural modifications at amide and aromatic rings and thus offer broad structure-activity variations. All the compounds have been tested against adult as well as immature Schistosoma mansoni. Compounds 15 and 18 show moderate activity against adult schistosomes. On immature worms, only compound 15 shows substantial activity whereas the standard drug PZQ is practically inactive at this stage.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.56B(01) [January 2017]en_US
dc.subjectSchistosomiasisen_US
dc.subjectPraziquantelen_US
dc.subjectFuroxanen_US
dc.subjectHybrid drugen_US
dc.subjectSchistosoma mansonien_US
dc.subjectAntischistosomalen_US
dc.titleSynthesis and antischistosomal activity of new furoxan derivatives of praziquantelen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.56B(01) [January 2017]

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