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Title: Synthesis and antischistosomal activity of new furoxan derivatives of praziquantel
Authors: Kumar, Singam Naveen
Sadhu, Partha Sarathi
Sharma, Kirti Kumari
Pica-Mattoccia, Livia
Basso, Annalisa
Cioli, Donato
Rao, Vaidya Jayathirtha
Keywords: Schistosomiasis;Praziquantel;Furoxan;Hybrid drug;Schistosoma mansoni;Antischistosomal
Issue Date: Jan-2017
Publisher: NISCAIR-CSIR, India
Abstract: A series of new furoxan derivatives of praziquantel have been synthesized and evaluated for antischistosomal activity. The newly synthesized hybrid compounds have structural modifications at amide and aromatic rings and thus offer broad structure-activity variations. All the compounds have been tested against adult as well as immature Schistosoma mansoni. Compounds 15 and 18 show moderate activity against adult schistosomes. On immature worms, only compound 15 shows substantial activity whereas the standard drug PZQ is practically inactive at this stage.
Page(s): 112-119
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(01) [January 2017]

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