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http://nopr.niscpr.res.in/handle/123456789/39726| Title: | Synthesis and antischistosomal activity of new furoxan derivatives of praziquantel |
| Authors: | Kumar, Singam Naveen Sadhu, Partha Sarathi Sharma, Kirti Kumari Pica-Mattoccia, Livia Basso, Annalisa Cioli, Donato Rao, Vaidya Jayathirtha |
| Keywords: | Schistosomiasis;Praziquantel;Furoxan;Hybrid drug;Schistosoma mansoni;Antischistosomal |
| Issue Date: | Jan-2017 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of new furoxan derivatives of praziquantel have been synthesized and evaluated for antischistosomal activity. The newly synthesized hybrid compounds have structural modifications at amide and aromatic rings and thus offer broad structure-activity variations. All the compounds have been tested against adult as well as immature Schistosoma mansoni. Compounds 15 and 18 show moderate activity against adult schistosomes. On immature worms, only compound 15 shows substantial activity whereas the standard drug PZQ is practically inactive at this stage. |
| Page(s): | 112-119 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.56B(01) [January 2017] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 56B(1) 112-119.pdf | Main Article | 134.57 kB | Adobe PDF | View/Open |
| IJCB 56B(1) 112-119_Suppl Data.pdf | Supplementary Data | 1.08 MB | Adobe PDF | View/Open |
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