Synthesis of an amino moiety in trovafloxacin by using an in-expensive amidine base, <i style="">N,N</i>-diethylacetamidine

Abstract

<smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> The simple and in-expensive amidine base, <i style="">N,N</i>-diethylacetamidine, has been prepared and utilized in the construction of bicyclic hetero compound, <b style="">4</b> and employed for further reduction of amidic carbonyl groups of <b style="">4</b> by using NaBH₄/I₂-THF condition which is an efficient and commercially viable method to prepare <b style="">5</b> towards the synthesis of amino moiety <b style="">1</b>, in Trovafloxacin <b style="">2 </b>an antibacterial agent. </smarttagtype>