Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/36894
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dc.contributor.authorDasari, Pitchaiah-
dc.contributor.authorNayak, Prasunpriya-
dc.date.accessioned2016-11-08T09:25:17Z-
dc.date.available2016-11-08T09:25:17Z-
dc.date.issued2016-11-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/36894-
dc.description729-734en_US
dc.description.abstractTocotrienols are members of vitamin E family present in low concentrations and possess high antioxidant activity. Consumption of ethanol is a common problem and induces oxidative stress. In this study, we evaluated the effect of tocotrienol against ethanol-induced oxidative stress. Male albino Wistar rats were divided into two sets; one set of rats were exposed with low to moderate doses of ethanol for 4 weeks, while another set was exposed to tocotrienol orally (10 mg/day) in addition to the ‘low to moderate doses of ethanol for 4 weeks’. Oxidative stress parameters, like levels of reduced glutathione and lipid peroxidation, activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase were determined in serum before the initiation of treatment protocol and at the end of 2nd and 4th week of treatment. Serum levels of superoxide and peroxide handling capacities were also calculated in those three time points. Tocotrienol-treated rats showed statistically significant enhancement in reduced glutathione level, glutathione peroxidase and glutathione reductase activities. Glutathione-dependent superoxide and peroxide handling capacity of those rats were found to be higher. The current study suggests that the tocotrienol-induced protection against the oxidative stress is most likely mediated by glutathione-based system.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.54(11) [November 2016]en_US
dc.subjectAUDsen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectGlutathione reductaseen_US
dc.subjectLipid peroxidationen_US
dc.subjectOxidative stressen_US
dc.subjectReduced glutathioneen_US
dc.titleEffect of Tocotrienol on medium dose ethanol-induced alternations in serum superoxide and peroxide handling capacities (SPHC) in raten_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.54(11) [November 2016]

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