Please use this identifier to cite or link to this item:
Title: Effect of ethanolic extract of Zingiber officinale Roscoe on Central Nervous System activity in mice
Authors: Sharma, Pradeep Kumar
Singh, Vijender
Ali, Mohammed
Kumar, Sokindra
Keywords: Antidepressant activity;Antinociceptive activity;Antioxidant;Anxiolytic activity;Depression;Diazepam;Ginger;Imipramine;Locomotor activity;Morphine
Issue Date: Oct-2016
Publisher: NISCAIR-CSIR, India 0975-1009 (Online); 0019-5189 (Print)
Abstract: Zingiber officinale Roscoe, commonly known as ginger, is a traditional herb used to treat various disorders. In this study, we evaluated potential pharmacological effects of ethanolic extracts of Z.Officinale with respect to central nervous system (CNS) activity in mice. Role of ethanolic extract of ginger on CNS activity in mice was studied using models of elevated plus maze test, barbiturate-induced sleeping time, tail suspension test, hot-plate and tail-flick test. Ginger extract was administered to mice at single doses of 50 and 200 mg/kg, perorally while diazepam (1 mg/kg), morphine (5 mg/kg) and imipramine (30 mg/kg) intraperitoneally were used as standard drugs. The results showed that the ginger extract at all dose levels significantly exhibited anxiolytic activity increased the sleeping latency but reduced the sleeping time. Tail suspension test showed that the extract at both the doses was able to induce a significant decrease in the immobility time, similar to imipramine, a recognized antidepressant drug. Tail-flick and hot-plate tests demonstrated antinociceptive property of ginger extract, similar to morphine, a recognized antinociceptive agent. Higher dose level (200 mg/kg) showed better protective effects. Phytochemical screening of ethanolic extract revealed the presence of various phytoconstituents such as phenolic compounds, flavonoids, tannins, anthocyanins, carbohydrates, glycosides, proteins, resins and volatile oils. The possible mechanism by which ginger exhibited the significant beneficial effects on various CNS models in mice could be attributed to its antioxidant potential.
Page(s): 664-669
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.54(10) [October 2016]

Files in This Item:
File Description SizeFormat 
IJEB 54(10) 664-669.pdf238.42 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.